Rating 4.5

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects ...

2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response.

Jan 9, 2019 · 2BAct prevented myelin loss and reactive gliosis in VWM mice. VWM is a leukoencephalopathy defined by progressive loss of myelin. In patients ...

2BAct is an activator of eukaryotic translation initiation factor 2B (eIF2B; EC50 = 33 nM in a reporter assay). It enhances eIF2B activity in primary ...

2BAct is a novel, potent, highly selective, CNS-permeable, and orally bioactive eif2b (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM, ...

Jan 9, 2019 · 2BAct normalized body weight gain and prevented motor deficits in male R191H mice. · 2BAct is an eIF2B activator with similar potency to ISRIB.

... 2BAct, prevents all measures of pathology and normalizes the transcriptome and proteome of VWM mice ... Small molecule ISRIB suppresses the integrated stress ...

2BAct ... defined by the immunopositive area as a percentage of the total area of the ...

Nov 5, 2018 · 2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response. Thus, 2BAct-like molecules ...